Clinical Science
Behind Reviiv | 

State-of-the-art dual-light therapy device
that delivers physio-level results from the comfort of your home.

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Meet Oxidative Stress:
The Dangerous By-Product Of Your Body Managing Oxygen.

Oxidative stress is a phenomenon caused by an imbalance between production and accumulation of reactive oxygen species (ROS) in cells and tissues and your body’s ability to detoxify these reactive products. A large body of evidences shows that oxidative stress can be responsible, with different degrees of importance, in the onset and/or progression of several diseases.

Osteoarthritis

DNA Damage

Chronic Inflammation

Cancer

Diabetes

Metabolic Disorders

Atherosclerosis

Cardiovascular

Oxidative Stress And Joint Problems: Common Problems With A Common Source.

Besides other agents – risk factors such as overweight or a family history, oxidative stress is involved in the pathogenesis of arthritis. OA is not limited to articular cartilage only, but also affects the subchondral bone, as well as the adjacent connective tissue and the synovial membrane.

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Nitric Oxide: The Pain Reliever You’ve Never Heard Of.

PBM relies on a photochemical mechanism. Specific wavelengths of light are used for the application, absorbed by chromophores present in the cells. PBM can also reduce oxidative stress by dissociating the inhibitory nitric oxide (NO) from CCO (Hamblin 2016).

Nitric Oxide is involved in perception and reduction of pain caused by OA via four different pathways:

blood-flow

Normalized and decrease ischemic pain.

nerve transmission

Decreases the irritation of the nerves in the synovium, bone and soft tissues.

opioid receptor

Stimulate the body’s normal pain reduction pathways.

anti-inflammation

Normalized and decrease ischemic pain.

87%

Of Individuals Reported A Decrease In Pain Symptoms

79%

Of Individuals Reported A Decrease In Pain Symptoms

87%

Showed An Improvement In Tissue Reperfusion (Indicating Healthier Blood Flow)

77%

Showed An Improvement In Tissue Reperfusion (Indicating Healthier Blood Flow)

The Balancing Power Of Light.

Light Therapy PBM shows beneficial* effects by:

*(Johnstone et al. 2016; Salehpour et al. 2018)

Increasing mitochondrial function

Reducing protein accumulation

Reducing oxidative stress

Suppressing inflammation

Reviiv's Activation in Action.

The KNEE+ improves blood flow, reduces oxidative stress and inflammation, and reduces pain by triggering cellular signaling processes. These benefits have been validated by a series of clinical studies, including hundreds of human trials.

From Blood Flow to Healing.

Reduced pain and lower inflammation markers. Increased blood flow from nitric oxide activation is one of the multiple positive impacts on cardio-vascular health like healing endothelial cells, Improving bone regeneration and increasing cartilage retention and regrowth.

From blood flow 
to healing.

Reduced pain and lower inflammation markers. Increased blood flow from nitric oxide activation 
is one of the multiple positive impacts on cardio-vascular health like healing endothelial Cells,Improving bone regeneration and Increasing 
cartilage retention and regrowth.

Pain Relief & Inflammation Reduction.

Clinical studies show how effectively reduces pain and inflammation. A significant majority of participants experienced the benefits of light therapy after wearing the KNEE+ device, with many still feeling the effects months later.

In a single session, Reviiv KNEE+ activates Nitric Oxide & increases blood flow.

Using a technique called reactive hyperemia, scientists tracked vascular activity during a single 5 minute KNEE+ session. They observed improved reperfusion in treated tissue, a type of activity that indicates better blood flow and vascular health.

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